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Growth and Neurodevelopmental Outcome in Preterm LBW Infants with Sepsis in India: A Prospective Cohort

Sunil J Pawar1,2, Tejopratap Oleti2, Siluvery Bharathi1

  • 1Durgabai Deshmukh Hospital and Research Center, Hyderabad, India.

International Journal of Pediatrics
|April 24, 2018
PubMed

Insights

Neonatal sepsis in low-birth-weight (LBW) infants is linked to abnormal neurodevelopmental outcomes. However, the study found no significant impact on growth at 9-15 months corrected age.

Area of Science:

  • Neonatal care
  • Pediatric neurology
  • Infant development

Background:

  • Neonatal sepsis is a serious infection in newborns.
  • Low-birth-weight (LBW) infants are particularly vulnerable to infections and long-term complications.
  • Previous research suggests potential links between neonatal infections and later developmental issues.

Purpose of the Study:

  • To investigate the association between neonatal sepsis and neurodevelopmental outcomes in LBW infants.
  • To assess the impact of neonatal sepsis on growth parameters in LBW infants.
  • To compare neurodevelopment and growth between LBW infants with and without neonatal sepsis.

Main Methods:

  • Prospective cohort study of 128 preterm LBW infants.
  • Infants admitted between 2013-2014.
  • Follow-up assessments at 9-15 months corrected age, comparing sepsis and nonsepsis groups.

Main Results:

  • 94 infants were evaluated (40 sepsis, 54 nonsepsis).
  • LBW infants with neonatal sepsis showed a significantly higher risk of neurodevelopmental disorders (67.5% vs 20.3%).
  • No statistically significant differences in growth outcomes were observed between the groups.

Conclusions:

  • Neonatal sepsis is associated with abnormal neurodevelopmental outcomes in LBW infants.
  • Growth outcomes at 9-15 months corrected age were not significantly different between infants with and without neonatal sepsis.
  • Early recognition and management of neonatal infections are crucial for optimizing neurodevelopmental trajectories in LBW infants.
Abstract

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