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GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact
Paula Nunes1, Nicolas Demaurex1
1Department of Cell Physiology and Metabolism, Rue Michel-Servet, 1, University of Geneva, Switzerland.
Cell Calcium
|April 24, 2018
Abstract:
GRAM domain proteins were reported as novel ER-PM tethers defining specific membrane contact sites (MCS) subdomains. GRAMD2a pre-marks the sites occupied by STIM1 at MCS and its ablation impairs STIM1 translocation, but not store-operated Ca2+ entry. We discuss these apparently counterintuitive findings in the context of STIM/ORAI signaling at MCS.