Related Experiment Video
Updated: Jul 31, 2026

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice
Published on: July 20, 2011
Alzheimer's disease Archimedes condition-event simulator: Development and validation.
Anuraag R Kansal1, Ali Tafazzoli1, K Jack Ishak2
1Modeling and Simulation, Evidera, Bethesda, MD, USA.
A new simulator, AD Archimedes, models Alzheimer's Disease (AD) progression to assess early interventions. This tool aids in evaluating disease-modifying treatments for Alzheimer's Disease, improving patient outcomes.
Area of Science:
- Biomedical Simulation
- Neurodegenerative Disease Modeling
- Pharmacoeconomics
Background:
- Existing Alzheimer's Disease (AD) models lack comprehensive disease progression scope.
- There is a need for tools to study early-stage and prodromal AD interventions.
Purpose of the Study:
- To develop a patient-level simulator for Alzheimer's Disease (AD) modeling.
- To simulate the effects of early interventions by tracking biomarker changes.
Main Methods:
- Developed the AD Archimedes condition-event simulator.
- Utilized interconnected predictive equations from longitudinal data.
- Focused on simulating early intervention effects via AD biomarkers.
Main Results:
- External validation showed reasonable estimates for AD progression, institutionalization, and mortality.
- A case study demonstrated the benefits of early treatment with disease-modifying therapies.
Conclusions:
- The AD Archimedes simulator enables economic evaluations of interventions.
- It facilitates close tracking of disease progression and clinical outcomes in AD.
More Related Videos
06:46Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
Published on: August 4, 2018
07:07Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze
Published on: October 29, 2019
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer's Disease: Treatment
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction