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Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
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853
Endoscopic Therapies for Gastroparesis.
Andrew Su1, Jeffrey L Conklin2,3, Alireza Sedarat2
1Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Suite 2114, Los Angeles, CA, 90095, USA. amsu@mednet.ucla.edu.
Current Gastroenterology Reports
|April 25, 2018
Summary
Gastroparesis treatment is challenging due to heterogeneous causes. Emerging endoscopic therapies, including gastric per-oral endoscopic myotomy (G-POEM), show promise but require further research for optimal patient selection and efficacy.
Area of Science:
- Gastroenterology
- Endoscopic Therapeutics
- Motility Disorders
Background:
- Gastroparesis presents a significant clinical challenge with limited effective treatments.
- Heterogeneous pathophysiology underlies gastroparesis, contributing to variable patient responses to therapy.
Purpose of the Study:
- To review current and emerging endoscopic treatment options for gastroparesis.
- To highlight gastric per-oral endoscopic myotomy (G-POEM) as a novel endoscopic approach.
Main Methods:
- Review of existing literature on endoscopic therapies for gastroparesis.
- Categorization of endoscopic options into pyloric-directed, non-pyloric-directed, and nutritional support.
Main Results:
- Gastric per-oral endoscopic myotomy (G-POEM) shows encouraging early results with an acceptable safety profile up to one year.
- Other pyloric-directed therapies like dilation and stenting have been investigated.
Conclusions:
- Emerging endoscopic therapies for gastroparesis are promising but require better understanding of pathophysiology and patient selection.
- Future research necessitates prospective, controlled studies to validate efficacy.
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