Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acid-Base Balance01:25

Acid-Base Balance

2.8K
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
2.8K
Disorders of Acid-Base Balance01:29

Disorders of Acid-Base Balance

2.1K
The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
2.1K
Substituent Effects on Acidity of Carboxylic Acids01:31

Substituent Effects on Acidity of Carboxylic Acids

7.9K
The acidity of carboxylic acids is influenced by the nature of the substituents bounded to the functional group. The acid strength is determined by the stability of the carboxylate anion—the conjugate base formed by dissociating the corresponding carboxylic acid.
7.9K
Respiratory Regulation of Acid-Base Balance01:18

Respiratory Regulation of Acid-Base Balance

1.8K
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2​​ and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
1.8K
Renal Regulation of Acid-Base Balance01:29

Renal Regulation of Acid-Base Balance

1.9K
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
1.9K
Nucleic Acids02:43

Nucleic Acids

50.7K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
50.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute Toxic Leukoencephalopathy: Opioid and other Illicit or Abused Drugs and Environmental Toxins.

Neuroimaging clinics of North America·2026
Same author

Decreasing Prevalence of Chronic Kidney Disease Among U.S. Adults With Diabetes, 1999-2018.

AJPM focus·2026
Same author

Nephrolithiasis: A Paleolithic Perspective and Physiological Approach to Prevention.

Annual review of medicine·2026
Same author

Lower Neighborhood Socioeconomic Status Is Associated With Intensive Care Unit Admission at Initial Presentation in Children With Acute Leukemia.

Pediatric blood & cancer·2025
Same author

Impact of neighborhood archetypes on overall mortality among young patients with acute leukemia in California.

Cancer·2025
Same author

Correction: Beyond hypertrophic cardiomyopathy: unmasking alternative causes of LVOT obstruction on CMR.

The international journal of cardiovascular imaging·2025

Related Experiment Video

Updated: Feb 11, 2026

Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans
09:38

Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans

Published on: November 29, 2013

17.6K

Acid Balance, Dietary Acid Load, and Bone Effects-A Controversial Subject.

Lynda Frassetto1, Tanushree Banerjee2, Neil Powe3

  • 1Deparment of Medicine, University of California, San Francisco, CA 94143, USA. lynda.frassetto@ucsf.edu.

Nutrients
|April 26, 2018
PubMed
Summary

Western diets high in acid precursors may contribute to bone loss and osteoporosis. Consuming more alkaline foods or alkali supplements could potentially mitigate this acid-related bone damage.

Keywords:
agingalkalikidneyosteoporosis

More Related Videos

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

797
Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
06:32

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts

Published on: April 13, 2022

2.1K

Related Experiment Videos

Last Updated: Feb 11, 2026

Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans
09:38

Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans

Published on: November 29, 2013

17.6K
Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

797
Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
06:32

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts

Published on: April 13, 2022

2.1K

Area of Science:

  • Nutritional Science
  • Bone Metabolism
  • Metabolic Acidosis

Background:

  • Modern Western diets are rich in acid precursors, potentially leading to a net acid load.
  • The body utilizes buffering systems, including bone mineral, to neutralize acid.
  • Dietary acid load is hypothesized to contribute to bone mass loss and osteoporosis.

Purpose of the Study:

  • To explore the link between high-acid diets and bone loss.
  • To review evidence for and against alkali therapy in osteoporosis treatment.
  • To reconcile conflicting findings on diet-induced acidosis and bone health.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Analysis of dietary acid-base balance and aging.
  • Examination of studies on alkali therapy for osteoporosis.

Main Results:

  • Evidence exists supporting and opposing the hypothesis that high-acid diets cause bone loss.
  • Conflicting data on the efficacy of alkali therapy for osteoporosis treatment.
  • The study aims to reconcile these discordant findings.

Conclusions:

  • Dietary acid-base balance may influence bone health.
  • Alkali therapy presents a potential, though debated, strategy for managing osteoporosis.
  • Further research is needed to clarify the role of diet in bone metabolism and osteoporosis.