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Updated: Feb 11, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Targeting Splicing in Prostate Cancer.

Effrosyni Antonopoulou1, Michael Ladomery2

  • 1Faculty of Health and Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK. londinoantonopoulou@hotmail.com.

International Journal of Molecular Sciences
|April 26, 2018
PubMed
Summary

Alternative splicing generates gene variants with opposing roles, impacting prostate cancer. Novel therapies targeting these splice isoforms or splicing machinery offer new treatment avenues.

Keywords:
ARBCL2L2ERGKLF6RNA interferenceVEGFAalternative splicingprostate cancersplice factor kinasessplice factorssplice switching oligonucleotides

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Over 95% of human genes undergo alternative splicing, producing splice isoforms with diverse, often opposing, functions.
  • Alternative splicing plays a critical role in the development and progression of various diseases, including cancer.

Purpose of the Study:

  • To identify and discuss genes and their splice isoforms implicated in prostate cancer.
  • To explore novel therapeutic strategies targeting alternative splicing in prostate cancer.

Main Methods:

  • Review and analysis of scientific literature linking specific genes to prostate cancer via alternative splicing.
  • Discussion of potential therapeutic modalities targeting splice isoforms and splicing machinery.

Main Results:

  • Identification of key genes (VEGFA, KLF6, BCL2L2, ERG, AR) with alternative splicing linked to prostate cancer.
  • Elucidation of the antagonistic functional roles of certain splice isoforms.

Conclusions:

  • Targeting specific splice isoforms or the splicing machinery presents a promising avenue for novel prostate cancer therapies.
  • Therapeutic approaches include small molecule inhibitors, siRNAs, and splice switching oligonucleotides.