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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Pulmonary Hypertension: Classification and Pathogenesis01:30

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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Cystic Fibrosis: Pathogenesis01:23

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
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Leptospiral Genomics and Pathogenesis.

Dieter Bulach1, Ben Adler2

  • 1Melbourne Bioinformatics, The University of Melbourne, Carlton, VIC, Australia.

Current Topics in Microbiology and Immunology
|April 27, 2018
PubMed
Summary
This summary is machine-generated.

Genomic and molecular research has significantly advanced the understanding of leptospirosis pathogenesis. New techniques enabled the study of pathogenic Leptospira, revealing key biological and taxonomic insights.

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Area of Science:

  • Microbiology
  • Genomics
  • Pathogenesis research

Background:

  • The molecular basis of leptospirosis pathogenesis was largely unknown until recently.
  • Advances in sequencing technologies have been crucial for leptospiral research.

Purpose of the Study:

  • To analyze recent progress in understanding Leptospira taxonomy and biology.
  • To discuss the impact of genomics and mutagenesis on leptospirosis research.

Main Methods:

  • Whole genome sequencing of pathogenic Leptospira species.
  • Development and application of transposon and directed mutagenesis.
  • Integration of genomics, transcriptomics, and mutant characterization.

Main Results:

  • Significant progress in understanding Leptospira taxonomy and biology.
  • Identification of molecular and cellular mechanisms of pathogenesis.
  • Enabled detailed study of pathogenic Leptospira strains.

Conclusions:

  • Genomic and molecular tools have revolutionized leptospirosis research.
  • Current understanding of Leptospira pathogenesis is greatly enhanced.
  • Continued research promises further insights into this infectious disease.