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Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
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Contact Lenses for Color Blindness
Abdel-Rahman Badawy1, Muhammad Umair Hassan1, Mohamed Elsherif1
1School of Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Advanced Healthcare Materials
|April 27, 2018
Summary
New contact lenses incorporating a rhodamine derivative can filter specific wavelengths to aid individuals with inherited color vision deficiency. This innovative approach offers a potentially more accessible and compatible solution for managing color blindness.
Area of Science:
- Ophthalmology
- Genetics
- Materials Science
Background:
- Color vision deficiency (color blindness) is an inherited genetic ocular disorder.
- Current management options, like specialized glasses, are costly and cumbersome.
- Existing solutions may not be compatible with other vision correction needs.
Purpose of the Study:
- To develop a novel method for managing color vision deficiency.
- To incorporate a rhodamine derivative into commercial contact lenses for wavelength filtering.
- To assess the biocompatibility and effectiveness of these dyed contact lenses.
Main Methods:
- Incorporation of a rhodamine derivative into commercial contact lenses.
- Wavelength filtering in the ≈545-575 nm range to correct color vision.
- Biocompatibility testing using human corneal fibroblasts and epithelial cells.
Main Results:
- The dyed contact lenses successfully filtered specific wavelength bands.
- Biocompatibility assessments showed no toxicity to corneal cells.
- Cell viability remained high (99%) after 72 hours of exposure.
Conclusions:
- Dyed contact lenses show significant potential for wavelength filtering.
- This technology offers a promising avenue for managing color vision deficiency.
- The developed contact lenses are biocompatible and effective for color vision management.
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