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Updated: Feb 11, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Multicomponent peptide assemblies.

Danielle M Raymond¹, Bradley L Nilsson

¹Department of Chemistry, University of Rochester, Rochester, NY 14627-0216, USA. nilsson@chem.rochester.edu.

Chemical Society Reviews

|April 27, 2018

Summary

This summary is machine-generated.

Multicomponent peptide assemblies offer unique properties for advanced applications. This review explores their design, structure, and emergent properties for next-generation bio-inspired materials in medicine and energy.

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Area of Science:

Biomaterials Science
Nanotechnology
Chemical Engineering

Background:

Self-assembled peptide nanostructures are valuable functional materials.
Multicomponent peptide assemblies exhibit unique emergent properties.
These properties expand the functional utility of peptide-based materials.

Purpose of the Study:

To review recent advancements in multicomponent peptide assemblies.
To discuss the design, structure, emergent properties, and applications of these assemblies.
To highlight their potential as sophisticated next-generation bio-inspired materials.

Main Methods:

Review of literature on multicomponent peptide assemblies.
Analysis of assemblies derived from various peptide types (short peptides, peptide amphiphiles, coiled coils, collagen, β-sheets).
Examination of design principles, structural characteristics, and resulting properties.

Main Results:

Multicomponent assemblies demonstrate diverse emergent properties.
Specific examples include assemblies from short low molecular weight peptides, peptide amphiphiles, coiled coil peptides, collagen, and β-sheet peptides.
These assemblies show significant potential for expanded applications.

Conclusions:

Multicomponent peptide assemblies represent a sophisticated class of bio-inspired materials.
Their unique emergent properties are key to their advanced functional utility.
Further development holds promise for innovations in biomedicine and energy sectors.