TREATMENT OF TOXIC THYROID ADENOMA BY THE ETHANOL DESTRUCTION METHOD

The aim of study was to evaluate the long-term results and complications of percutaneous ethanol injection therapy of the thyroid gland toxic adenoma for a 10-year follow-up period. We conducted a 10-year prospective cohort study of the ethanol sclerotherapy results in 43patients with toxic adenomas of the thyroid gland aged in average 62.59 (57.95-65.73) years and a duration of the disease of 17.7 (10.8-22.20) years. As a result of the study, we found that ethanol sclerotherapy can achieve a significant reduction in the volume of adenomas based on the results of ultrasound during the 10-year observation period: the average volume after the procedure was 4.27 cm3 vs. initial - 21.12 cm3, p <0.00, and absence of the disease recurrence. The incidence of complications, including temporary local pain and transient dysphonia was 0.07±0.02% of cases. The patients quality of life during the 12 months of observation was significantly higher than the baseline data (Physical component: 71.96 (71.35-72.84) points after treatment versus 47.47 (47.18-47.82) (Z = -5711, p <0.00 ) Psychic component: 81.35 (78.34-85.49) points after therapy against 53.00 (52.11-54.11) points at the initial examination (Z = -5.711, p<0.00)). According to results we concluded, that the treatment of toxic thyroid adenoma by the ethanol destruction method is an effective, safe, low-cost method of therapy that has a significantly positive effect on the patients' quality of life.