Related Experiment Video
Updated: Feb 11, 2026

Genome Editing in Mammalian Cell Lines using CRISPR-Cas
Published on: April 11, 2019
Non-genomic regulation of mammalian sperm hyperactivation
1Department of Physiology, School of Medicine Dokkyo Medical University 321-0293 Mibu Tochigi Japan.
Abstract:
Although it has been suggested that the acrosome reaction is induced through non-genomic regulation in a ligand-dependent manner, it is not known whether hyperactivation is similarly regulated. Progesterone and melatonin have been identified as ligands that regulate hyperactivation, the former through non-genomic regulation with phospholipase C and the latter most likely through a reactive oxygen species-mitogen activated protein kinase cascade. Both may be involved in spontaneous regulation of hyperactivation via tyrosine phosphorylation. The concentration of many hormones changes according to environmental conditions and biological rhythms, which will modulate ligand-dependent regulation of hyperactivation.
Related Concept Videos
Genomics
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Sperm Transport
The maturation phase occurs in the epididymis, where sperm...
Epigenetic Regulation
Cooperative Binding of Transcription Regulators
GTPases and their Regulation
Large G-proteins,...

