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Related Experiment Video

Updated: Feb 11, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Dark Rims: Novel Sequence Enhances Diagnostic Specificity in Multiple Sclerosis.

J-M Tillema1, S D Weigand2, M Dayan3

  • 1From the Departments of Neurology (J.-M.T., M.D., O.H.K., C.F.L.) tillema.janmendelt@mayo.edu.

AJNR. American Journal of Neuroradiology
|April 28, 2018
PubMed
Summary
This summary is machine-generated.

A new MRI technique using GM-double inversion recovery improves multiple sclerosis (MS) diagnosis specificity. This method helps distinguish MS lesions from other white matter conditions, reducing misdiagnosis risks.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • The 2010 McDonald criteria for multiple sclerosis (MS) diagnosis offer high sensitivity but can lack specificity, potentially leading to misdiagnosis.
  • Distinguishing MS from other white matter lesions is a diagnostic challenge.

Purpose of the Study:

  • To evaluate a novel double inversion recovery magnetic resonance (MR) imaging technique for enhancing the specificity of MS diagnostic criteria.
  • To assess the potential of GM-double inversion recovery MR imaging in differentiating MS from non-MS white matter lesions.

Main Methods:

  • A cross-sectional observational study comparing MR imaging data from patients with MS and control subjects with white matter lesions.
  • Utilized a novel GM-double inversion recovery sequence to suppress cerebrospinal fluid (CSF) and gray matter (GM) signals.
  • Analyzed lesion characteristics, including the presence of a rim on GM-double inversion recovery images, in conjunction with McDonald criteria.

Main Results:

  • Analysis included 107 patients with relapsing-remitting MS and 36 control subjects.
  • A rim on GM-double inversion recovery MR imaging was observed in 35% of MS lesions versus 1% of control lesions.
  • Combining 2010 McDonald criteria with the presence of rim lesions achieved 78% and 97% specificity for MS diagnosis with ≥1 and ≥2 rim lesions, respectively.

Conclusions:

  • The novel GM-double inversion recovery MR imaging technique significantly enhances diagnostic specificity for MS.
  • This technique offers a valuable addition to established MR imaging criteria for more accurate MS diagnosis.