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[Allergies to 8-hydroxyquinoline derivatives].

D Hutzler1, I Pevny

  • 1Dermatologischen Klinik und Poliklinik, Universität Würzburg.

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|May 1, 1988
PubMed
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Vioform and Sterosan allergies were observed in 1.2% and 1.1% of cases, respectively, with a rising trend over 12 years. These findings support their inclusion in standard allergy testing batteries.

Area of Science:

  • Dermatology
  • Allergology
  • Clinical Immunology

Background:

  • Vioform and Sterosan are topical antimicrobial agents.
  • Allergic contact dermatitis is a common adverse reaction to topical medications.
  • Standardized patch testing is crucial for identifying allergens.

Purpose of the Study:

  • To evaluate the prevalence and trends of Vioform and Sterosan allergies over a 12-year period.
  • To determine the justification for including Vioform and Sterosan in standard allergy testing.
  • To compare allergy frequencies between different patient groups.

Main Methods:

  • Retrospective analysis of standardized patch test results from 1972 to 1983.
  • Calculation of annual and overall allergy frequencies for Vioform and Sterosan.

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  • Comparison of results with existing literature data.

    • Main Results:

    • Vioform allergies were found in 1.2% and Sterosan allergies in 1.1% of cases.
    • Allergy rates showed an increasing trend over the study period, reaching 1.7% each in the final year.
    • Literature data for Vioform and Sterosan allergies range from 0.3% to 5.1% and 0.3% to 3.7%, respectively.
    • Patients with leg ulcers/chronic venous insufficiency had 3-4 times higher rates of Vioform and Sterosan allergies compared to eczema patients.

    Conclusions:

    • The observed prevalence and increasing trend of Vioform and Sterosan allergies justify their inclusion in standard patch test batteries.
    • Higher allergy rates in patients with leg ulcers and chronic venous insufficiency highlight the importance of considering these agents in specific patient populations.