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Updated: Feb 11, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Rectal cancer presenting with synchronous intraperitoneal spread of disease
Andrew Leiker1, Gaurav Khatri2, Jeffrey Meyer3
1Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Abstract:
There are differing definitions regarding what portion of the large intestine should be considered "rectum" as opposed to "colon." The transition from intra- to extraperitoneal rectum results in potentially disparate patterns of spread for rectal cancer dependent on tumor location relative to the peritoneal reflection. Here we report the case of a 50-year-old woman with a mid to upper rectal adenocarcinoma who presented with a synchronous biopsy-proven tumor implant in the peritoneal cavity. Her case highlights issues of varying definitions of organ anatomy within the literature, the role of primary tumor localization within different compartments of the abdominopelvic cavity for predicting potential routes of tumor spread, and the implications for adjuvant therapies.
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