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The Family Approach to the Resolution of Racemates
Ton Vries1, Hans Wynberg1, Erik van Echten1
1Syncom BV, Nijenborgh 4, NL-9747 AG Groningen (The Netherlands), Fax: (+31) 50-363-4875.
Abstract:
The resolution of racemates is revolutionized with the method presented here, in which mixtures ("families") of structurally and stereochemically related resolving agents are used to precipitate salts of acidic or basic racemates rapidly and dependably. The racemate is usually separated in a single operation into enantiomers-the enantiomeric excesses and yields are good to excellent. Reagent mixtures with racemic or achiral components have also been developed.
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