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Updated: Feb 11, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
Total Syntheses of Vancomycin and Eremomycin Aglycons
David A Evans1, Michael R Wood1, B Wesley Trotter1
1Department of Chemistry & Chemical Biology, Harvard University Cambridge, MA 02138 (USA), Fax: (+1) 617-495-1460.
Abstract:
Controlling the elements of planar and axial chirality are the principal challenges in the synthesis of the aglycon of vancomycin. Vancomycin is the prototypical member of the glycopeptide family of antibiotics which are effective for the treatment of infections by methicillin-resistant Staphylococcus aureus. The first total syntheses of the vancomycin and eremomycin aglycons provide insight into the influence of structure on kinetic and thermodynamic control of atropselective macrocyclizations.
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