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Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel
Anna J Simon1, Luke T Walls-Smith, Kevin W Plaxco
1Biomolecular Science and Engineering Program, University of California Santa Barbara, Santa Barbara, CA 93106, USA. kwp@ucsb.edu.
The Analyst
|May 2, 2018
Abstract:
The sequence-specific hybridization and molecular recognition properties of DNA support the construction of stimulus-responsive hydrogels with precisely controlled crosslink geometry. Here we show that, as predicted by the conformational selection mechanism, the response kinetics of such a hydrogel can be tuned over orders of magnitude by modulating the thermodynamic stability of its crosslinks.