Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

38.2K
The Concept of Multiple Allelism
38.2K
Subviral Agents01:29

Subviral Agents

585
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
585
Multiple Regression01:25

Multiple Regression

4.0K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
4.0K
Air-entraining Agents01:27

Air-entraining Agents

276
Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...
276
Multiple Voltage Sources01:25

Multiple Voltage Sources

1.8K
Generally, a single battery is not enough to power some devices. In such cases, batteries can be combined in two ways: in series or in parallel.
In series, the positive terminal of one battery is connected to the negative terminal of another battery. Hence, the voltage of each battery is added to give the net voltage, which is increased because each battery boosts the electrons that enter it. The same current flows through each battery because they are connected in series.
Batteries are...
1.8K
Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

488
When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
488

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation.

Cancer research communications·2024
Same author

Rapid Progress in Immunotherapies for Multiple Myeloma: An Updated Comprehensive Review.

Cancers·2021
Same author

Monoclonal Antibody Therapies in Multiple Myeloma: A Challenge to Develop Novel Targets.

Journal of oncology·2019
Same author

Novel Antibody-Drug Conjugate with Anti-CD26 Humanized Monoclonal Antibody and Transcription Factor IIH (TFIIH) Inhibitor, Triptolide, Inhibits Tumor Growth via Impairing mRNA Synthesis.

Cancers·2019
Same author

Primary isolated bone marrow diffuse large B cell lymphoma with long-term complete remission.

Leukemia research reports·2019
Same author

CD26 is a potential therapeutic target by humanized monoclonal antibody for the treatment of multiple myeloma.

Blood cancer journal·2018
Same journal

The Global Gap in the Hemophilia Paradigm Shift: Disparities in Research, Care, and Musculoskeletal Health.

Hematology reports·2026
Same journal

Digital Symptom Reporting for Treatment Readiness Before Daratumumab: A Blinded Prospective Study in Multiple Myeloma.

Hematology reports·2026
Same journal

Quality of Life in CAR-T Cell Therapy.

Hematology reports·2026
Same journal

Eltrombopag for Chemotherapy-Induced Thrombocytopenia: A Multicenter Retrospective Real-World Study.

Hematology reports·2026
Same journal

Establishing Reference Intervals for White Blood Cell and Absolute Neutrophil Counts in Duffy Null Individuals.

Hematology reports·2026
Same journal

Perioperative Anemia, Transfusion Practices, and Patient Blood Management: Lessons from the COVID-19 Pandemic.

Hematology reports·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
07:53

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

4.8K

Bone-targeted agents in multiple myeloma.

Hiroko Nishida1

  • 1Department of Pathology, Keio University, School of Medicine, Tokyo, Japan.

Hematology Reports
|May 4, 2018
PubMed
Summary
This summary is machine-generated.

Multiple myeloma bone disease causes pain and fractures. Targeting the myeloma cell and bone microenvironment interaction is key to preventing skeletal-related events and improving patient survival.

Keywords:
bisphosphonatemultiple myelomanovel bone-targeted agentsosteoclastquality of lifeskeletal-related events

More Related Videos

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

9.1K
Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

7.2K

Related Experiment Videos

Last Updated: Feb 11, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
07:53

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

4.8K
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

9.1K
Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

7.2K

Area of Science:

  • Oncology
  • Bone Biology
  • Hematology

Background:

  • Multiple myeloma (MM) frequently causes osteolytic bone disease, leading to skeletal-related events (SREs) like fractures and hypercalcemia.
  • This bone disease significantly impacts patient morbidity and mortality, persisting even with controlled myeloma.
  • The bone marrow microenvironment facilitates a cycle of myeloma cell growth and bone destruction.

Purpose of the Study:

  • To review the pathophysiology of MM-associated bone disease.
  • To summarize current clinical management strategies for MM bone disease.
  • To discuss novel therapeutic targets and agents for MM bone disease.

Main Methods:

  • Literature review of pathophysiology and clinical management of MM bone disease.
  • Summary of current treatments, including nitrogen-containing bisphosphonates.
  • Discussion of emerging bone-targeted agents in preclinical development.

Main Results:

  • MM bone disease involves complex interactions between myeloma cells and bone marrow cells (osteoclasts, stromal cells, osteoblasts).
  • Therapeutic strategies targeting these interactions are crucial for tumor control and SRE prevention.
  • Novel agents targeting the MM bone disease cycle are under investigation.

Conclusions:

  • Understanding the MM bone disease cycle is vital for developing effective treatments.
  • Targeting the myeloma cell-bone microenvironment interaction offers a promising approach to manage SREs.
  • Future research and novel agents aim to improve quality of life and survival for MM patients.