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Dehydroepiandrosterone sulfate in saliva
A Lagrelius1, M Fridström, G Möllerström
1Department of Obstetrics and Gynecology, Karolinska Institutet, Huddinge University Hospital, Sweden.
Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1988
Summary
Saliva and serum dehydroepiandrosterone sulfate (DHAS) levels show poor correlation and variable ratios. Salivary DHAS assays are not clinically suitable due to inconsistent results compared to serum measurements.
Area of Science:
- Endocrinology
- Biochemistry
- Clinical Chemistry
Background:
- Dehydroepiandrosterone sulfate (DHAS) is an important steroid hormone precursor.
- Understanding DHAS concentrations in different biological fluids is crucial for clinical assessment.
Purpose of the Study:
- To investigate the relationship between dehydroepiandrosterone sulfate (DHAS) concentrations in saliva and serum.
- To evaluate the influence of sex, age, and oral contraceptive use on these concentrations.
Main Methods:
- Quantification of DHAS in saliva and serum samples from healthy men and women.
- Analysis of DHAS levels in relation to age and oral contraceptive use.
Main Results:
- Serum DHAS levels were higher in men than women and negatively correlated with age in non-OC users.
- Sex- and age-related differences were not observed in salivary DHAS.
- Salivary and serum DHAS showed poor correlation and variable ratios, with lower ratios in oral contraceptive users.
Conclusions:
- The inconsistent relationship between salivary and serum DHAS concentrations makes salivary assays unreliable for clinical use.
- Further research may be needed to understand the factors influencing DHAS distribution in saliva.