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Related Concept Videos

Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acids02:43

Nucleic Acids

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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
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Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

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Framework-Nucleic-Acid-Enabled Biosensor Development.

Fan Yang1,2, Qian Li2, Lihua Wang2

  • 1School of Laboratory Medicine , Hubei University of Chinese Medicine , 1 Huangjia Lake West Road , Wuhan 430065 , China.

ACS Sensors
|May 4, 2018
PubMed
Summary
This summary is machine-generated.

Framework nucleic acids (FNAs) offer programmable nanostructures for biosensing in various environments. This review highlights FNA advancements for precise diagnostics and bioimaging applications.

Keywords:
DNA nanostructuresbiosensorframework nucleic acidsin vitro detectionintracellular sensing

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Area of Science:

  • Biotechnology and Nanotechnology
  • Molecular Biology
  • Biosensing

Background:

  • Nucleic acids are programmable building blocks for nanostructures.
  • Framework nucleic acids (FNAs) offer tailorable functionality and precise addressability.
  • FNAs show significant promise for diverse biomedical applications.

Purpose of the Study:

  • To review recent advancements in framework nucleic acid (FNA)-enabled biosensing.
  • To explore FNA applications in homogeneous solutions, on surfaces, and within cells.
  • To discuss strategies for interfacial engineering and multiplexed detection using FNAs.

Main Methods:

  • Summarizing research on FNA-based biosensors.
  • Describing strategies for translating FNA structural properties to interfacial engineering.
  • Detailing approaches for multiplexed in vitro detection.

Main Results:

  • FNAs enable precise control over interfacial engineering.
  • Multiplexing strategies allow for highly parallel in vitro detection.
  • FNA-based biosensing is demonstrated in solution, on surfaces, and intracellularly.

Conclusions:

  • Framework nucleic acids are versatile tools for advanced biosensing.
  • FNA technology can be integrated with emerging technologies for next-generation biosensors.
  • Future applications include precision diagnostics and enhanced bioimaging.