Related Experiment Video
Updated: Feb 11, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Pd(II)-Catalyzed Cyclization-Oxidation of Urea-Tethered Alkylidenecyclopropanes
1State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis , University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.
Abstract:
A Pd(OAc)2-catalyzed intramolecular oxidative cyclization of urea-tethered alkylidenecyclopropanes with urea as a nitrogen source through a Pd(II)/Pd(IV) catalytic cycle has been presented, giving the corresponding cyclobuta[ b]indoline derivatives in moderate to good yields with a broad substrate scope. The reaction proceeds through a ring expansion of alkylidenecyclopropane along with the nucleophilic attack of nitrogen atom onto the in situ generated palladium carbenoid species as well as an oxidation process.
Related Concept Videos
Pyruvate Oxidation
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
Urea Cycle
Oxidation Numbers
PD Controller: Design
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
Time-Domain Interpretation of PD Control
Consider the example of control of motor torque. Initially, a positive...
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization

