Related Experiment Video
Updated: Jan 28, 2026
07:28
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
Published on: October 11, 2024
724
Living Donor Intestinal Transplantation.
Ivo G Tzvetanov1, Kiara A Tulla1, Giuseppe D'Amico1
1Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Suite 402, Chicago, IL 60612, USA.
Gastroenterology Clinics of North America
|May 9, 2018
Summary
Living donor intestinal transplantation (LDIT) offers results comparable to deceased donor transplants. It is best suited for specific pediatric cases and highly sensitized patients, potentially improving outcomes and survival rates.
Area of Science:
- Organ transplantation
- Surgical innovation
- Pediatric gastroenterology
Background:
- Living donor intestinal transplantation (LDIT) outcomes have improved significantly.
- LDIT results are now comparable to deceased donor intestinal transplantation.
- Careful patient selection and specific indications are crucial for successful LDIT.
Purpose of the Study:
- To evaluate the indications and patient selection criteria for living donor intestinal transplantation.
- To highlight the benefits of LDIT in specific patient populations.
- To discuss the immunologic advantages of LDIT in certain scenarios.
Main Methods:
- Review of current literature and clinical outcomes of LDIT.
- Analysis of patient selection criteria for LDIT.
- Comparison of LDIT outcomes with deceased donor intestinal transplantation.
Main Results:
- LDIT demonstrates outcomes comparable to deceased donor transplants.
- Combined living donor intestinal/liver transplantation in pediatric recipients with combined intestinal and hepatic failure is a primary indication.
- LDIT can potentially benefit highly sensitized recipients and those with HLA-identical donors.
Conclusions:
- LDIT is a viable option for specific indications, particularly in pediatric combined intestinal/liver failure cases.
- Minimizing waiting time through LDIT can reduce mortality.
- LDIT offers significant immunologic advantages in cases involving identical twins or HLA-identical siblings.
Related Concept Videos
01:23Anatomy of the Intestines
87.2K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.2K
01:15Small Intestine
3.8K
The small intestine is primarily responsible for digestion and nutrient absorption. It spans from the pyloric sphincter to the ileocecal valve and connects to the large intestine.
The small intestine is divided into three main sections - the duodenum, jejunum, and ileum. The duodenum, approximately 25 cm long, is nearest the stomach. It acts as a 'mixing bowl,' where chyme (partially digested food) blends with digestive enzymes from the pancreas and liver. The duodenum's unique...
The small intestine is divided into three main sections - the duodenum, jejunum, and ileum. The duodenum, approximately 25 cm long, is nearest the stomach. It acts as a 'mixing bowl,' where chyme (partially digested food) blends with digestive enzymes from the pancreas and liver. The duodenum's unique...
3.8K
01:09Large Intestine
4.9K
The large intestine is divided into three main regions: the cecum, colon, and rectum. Extending from the ileocecal valve to the anus, it frames the small intestine on three sides.
The ileocecal sphincter, a mucous membrane fold, guards the opening from the ileum to the large intestine. This valve permits material from the small intestine to pass into the large intestine. Attached to the ileocecal valve is the cecum. This small pouch, approximately 6 cm long, has a twisted, coiled tube known as...
The ileocecal sphincter, a mucous membrane fold, guards the opening from the ileum to the large intestine. This valve permits material from the small intestine to pass into the large intestine. Attached to the ileocecal valve is the cecum. This small pouch, approximately 6 cm long, has a twisted, coiled tube known as...
4.9K
01:26Histology of the Large Intestine
3.0K
The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
3.0K
01:27Histology of the Small Intestine
3.7K
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
3.7K
01:29Bacterial Flora of the Large Intestine
1.7K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.7K