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Related Concept Videos

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Related Experiment Video

Updated: Feb 10, 2026

Intravenous Injections in Neonatal Mice
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Intravenous lidocaine.

Jean-Pierre Estebe1

  • 1Department of Anesthesiology, Intensive Care, and Pain Medicine, University of Rennes, CHU of Rennes, Rue H Le Guilloux, 35033, Rennes, Cedex 9, France.

Best Practice & Research. Clinical Anaesthesiology
|May 10, 2018
PubMed
Summary
This summary is machine-generated.

Lidocaine, used as a general anesthetic adjuvant, offers significant analgesic benefits and improves postoperative outcomes. Its administration, particularly via continuous infusion, enhances patient satisfaction and supports opioid-sparing anesthesia protocols.

Keywords:
analgesialidocaineopioid-free anesthesiapharmacokinetic and pharmacodynamicssafety

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Lidocaine exhibits analgesic, antihyperalgesic, and anti-inflammatory properties.
  • Its use as a general anesthetic adjuvant is established, but mechanisms remain unclear.
  • Lidocaine can mitigate nociception and cardiovascular responses to surgical stress.

Purpose of the Study:

  • To explore the benefits of lidocaine in anesthesia and postoperative pain management.
  • To highlight lidocaine's role in opioid-reduced or opioid-free anesthesia.
  • To emphasize its inclusion in enhanced recovery after surgery protocols.

Main Methods:

  • Utilized lidocaine as an initial bolus followed by continuous infusion.
  • Integrated lidocaine into general anesthesia protocols.
  • Applied recommended protocols for safe and effective administration.

Main Results:

  • Demonstrated clear analgesic benefits with lidocaine infusion.
  • Significantly improved postoperative outcomes and patient satisfaction.
  • Facilitated opioid-reduced and opioid-free anesthesia procedures.

Conclusions:

  • Lidocaine administration, especially continuous infusion, provides substantial analgesic advantages.
  • It is a valuable adjunct for enhancing postoperative recovery and patient satisfaction.
  • Wise implementation in enhanced recovery after surgery protocols ensures high safety and efficacy.