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Updated: Feb 10, 2026

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In Vitro Characterization of Histone Chaperones using Analytical, Pull-Down and Chaperoning Assays
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Enzalutamide and analytical interferences in digoxin assays
Marie Deguigne1, Marion Brunet1, Chadi Abbara2
1a Centre Antipoison-Toxicovigilance Grand Ouest , CHU Angers , Angers , France.
Clinical Toxicology (Philadelphia, Pa.)
|May 10, 2018
Summary
Enzalutamide may interfere with digoxin testing, leading to falsely elevated levels. This analytical interference was observed in two patients, highlighting the need for careful interpretation of digoxin results when enzalutamide is used.
Area of Science:
- Clinical Pharmacology
- Analytical Toxicology
- Oncology Drug Interactions
Background:
- Digoxin is a critical medication for managing cardiac conditions like atrial fibrillation.
- Enzalutamide is a widely used androgen receptor inhibitor for prostate cancer treatment.
- Potential drug-drug interactions between enzalutamide and digoxin require investigation.
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