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Updated: Feb 10, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
TYPE 2 DIABETES MELLITUS AND CEREBRAL SMALL VESSEL DISEASE (CASE REPORT)
1Pineo Medical Ecosystem, Department of Neurolo-gy, Tbilisi, Georgia.
Abstract:
Patients with type 2 diabetes mellitus have an increased risk of cardiovascular (CV) morbidity and mortality. Recently, brain has been described also as a target organ for diabetic microvascular complications. Cerebral small vessel disease (SVD) may cause lacunar infarcts and cognitive dysfunction. In our case a brain MRI scan showed distinct lesions, which are mainly caused and seen by long lasting diabetes and hypertension.
Insights
Type 2 diabetes mellitus increases cardiovascular risks. Long-term diabetes and hypertension can cause distinct brain lesions, indicating the brain is a target organ for diabetic microvascular complications.
Area of Science:
- Neurology
- Endocrinology
- Cardiology
Background:
- Type 2 diabetes mellitus is a significant risk factor for cardiovascular disease.
- Diabetic microvascular complications are increasingly recognized to affect the brain.
- Cerebral small vessel disease (SVD) is a known complication linked to diabetes and hypertension.
Observation:
- Brain magnetic resonance imaging (MRI) revealed distinct lesions.
- These lesions were observed in a patient with a history of long-standing diabetes and hypertension.
Findings:
- The observed brain lesions are associated with long-term diabetes.
- Hypertension appears to be a contributing factor to these diabetic microvascular complications.
- Cerebral small vessel disease may manifest as distinct lesions on MRI.
Implications:
- The brain is a target organ for diabetic complications, alongside the cardiovascular system.
- Early detection and management of diabetes and hypertension are crucial to prevent neurological damage.
- Further research is needed to understand the mechanisms of SVD in diabetic patients.
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