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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
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Neoadjuvant chemohyperthermia: Our experience after 10 years.
Alejandro Sousa Escandón1, Juan León Mata1, Daniel Sousa González1
1Servicio de Urología. Hospital Comarcal de Monforte. Monforte-Lugo. España.
Archivos Espanoles De Urologia
|May 11, 2018
Summary
Neoadjuvant chemohyperthermia (QHT) significantly reduces non-muscle-invasive bladder cancer (NMIBC) recurrence. This treatment shows comparable adverse event rates to standard mitomycin C (MMC) instillation, offering a promising option for NMIBC management.
Area of Science:
- Urology
- Oncology
- Medical Physics
Background:
- Non-muscle-invasive bladder cancer (NMIBC) poses a significant clinical challenge.
- Recurrence remains a primary concern in NMIBC management.
- Neoadjuvant intravesical therapies are crucial for improving outcomes.
Purpose of the Study:
- To evaluate the efficacy and safety of neoadjuvant recirculated intravesical chemohyperthermia (QHT) with mitomycin C (MMC) for NMIBC.
- To compare QHT with standard adjuvant MMC instillation.
- To assess recurrence rates and adverse events in middle-high risk NMIBC patients.
Main Methods:
- A case control study involving 104 patients with middle-high risk NMIBC.
- 43 patients received neoadjuvant recirculated intravesical QHT with MMC.
- 61 patients received standard adjuvant MMC instillation.
- Follow-up duration was 43 months (range: 3-108 months).
Main Results:
- Neoadjuvant QHT achieved a 63% complete response rate.
- The 5-year recurrence rate was 16.2% after QHT versus 26.2% after standard MMC.
- No tumor progression or metastatic deaths were observed in the QHT group.
- Adverse event rates were similar between QHT and standard MMC groups, with Grade 3 AEs at 9.3% vs. 6.5%.
Conclusions:
- Recirculating neoadjuvant QHT is effective in reducing NMIBC recurrence.
- QHT demonstrates comparable safety profile to passive MMC instillation.
- Neoadjuvant QHT represents a viable therapeutic option for NMIBC.
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