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Neurotransmitter receptor genotypes associated with mental and behavioral disorders
Ekrem Varoglu1, Adil Seytanoglu2, Esra Asilmaz3
1Department of Computer Engineering, Eastern Mediterranean University, Famagusta, North Cyprus 99628, Turkey.
Aim:
Investigation of association studies within the field of mental and behavioral disorders is of value given their complex molecular etiology including epistatic interactions of multiple genes with small effects.
Materials & Methods:
Utilizing biomedical text mining, associations are uncovered for all mental and behavioral conditions listed in Diagnostic and Statistical Manual of Mental Disorders Text Revision. Specifically, a computational pipeline is designed to retrieve neurotransmitter receptor variations from biomedical literature with a text mining approach, where unique polymorphisms are also mined.
Results:
Analyses of 1337 unique neurotransmitter receptors and 465 distinct conditions yield 1568 unique gene-disease associations.
Conclusion:
This study takes an unconventional approach to association studies and generates a novel dataset of associations for disorders such as major depression and schizophrenia, which provides a global perspective for their genetic etiology.
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