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Establishing 3D Endometrial Organoids from the Mouse Uterus
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Insufficient and Scant Endometrial Samples: Determining Clinicopathologic Outcomes and Consistency in Reporting
Emily A Goebel1, C Meg McLachlin, Helen C Ettler
1Department of Pathology and Laboratory Medicine, Western University and London Health Sciences Centre, London, Ontario, Canada.
Summary
Pathologists may not need to distinguish between "insufficient" and "scant" endometrial samples, as clinical management and repeat biopsy rates are similar. Both sample types warrant careful consideration for repeat sampling due to potential malignancy findings.
Area of Science:
- Gynecologic Pathology
- Reproductive Medicine
- Clinical Diagnostics
Background:
- Limited endometrial tissue samples lack standardized pathologic reporting criteria.
- Clinical follow-up for patients with scant or insufficient endometrial samples is inconsistent.
Purpose of the Study:
- To compare clinicopathologic outcomes for endometrial samples categorized as insufficient versus scant.
- To assess the consistency of pathologic reporting for limited endometrial tissue.
- To evaluate clinical management practices for these samples.
Main Methods:
- Retrospective chart review of patients with insufficient or scant endometrial samples (2010-2013).
- Survey of gynecologists regarding their management of patients with these samples.
- Blind review of 99 previously reported scant/insufficient samples by four independent reviewers.
Main Results:
- No significant difference in repeat biopsy rates between insufficient (33%) and scant (31%) samples.
- Higher, though not statistically significant, uterine malignancy rates in insufficient (19%) versus scant (9%) samples.
- Complete consensus among reviewers in only 57% of cases, indicating reporting variability.
Conclusions:
- The distinction between insufficient and scant endometrial samples may not be clinically necessary for pathologic reporting.
- Similar management and repeat biopsy rates suggest a unified approach.
- Both insufficient and scant samples require careful consideration for repeat sampling, especially given potential malignancy risks.
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