Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Counterfactual Thinking01:19

Counterfactual Thinking

278
Counterfactual thinking is a cognitive process wherein individuals mentally reconstruct alternative versions of past events, often beginning with “what if” or “if only.” This reflective mechanism plays a significant role in shaping emotional experiences and guiding future behavior. Though typically triggered by unfavorable or unexpected outcomes, counterfactual thinking can also emerge in mundane, everyday decisions and experiences, revealing its deep entrenchment in...
278
Critical Thinking01:19

Critical Thinking

1.2K
Critical thinking involves reflective and productive thinking and the evaluation of evidence. Critical thinkers seek to understand the deeper meaning of ideas, question assumptions, and make independent decisions about what to believe or do. Scientists, for instance, are often critical thinkers. Critical thinking also requires humility about what we know and don't know and the motivation to look beyond the obvious. It is essential for effective problem-solving.
Colleges and universities are...
1.2K
Creative Thinking01:25

Creative Thinking

1.3K
Creative thinking encompasses innovative and unconventional methods for addressing challenges, often leading to groundbreaking solutions. Instead of focusing solely on enhancing existing systems, such as increasing smartphone battery capacity, creative thinking might inspire advancements like energy-efficient batteries or processors that minimize power consumption. This multidimensional approach underscores the importance of exploring novel pathways to innovation.
Divergent thinking is the...
1.3K
Magical Thinking01:29

Magical Thinking

226
Magical thinking encompasses the belief in assumptions that defy logical reasoning yet appear intuitively convincing. It is a common psychological phenomenon that persists across various cultural and individual contexts. While these assumptions contradict empirical evidence and scientific laws, they often serve meaningful psychological roles in promoting emotional resilience and a sense of control, especially under stress or uncertainty.Thought-Action Fusion and the Law of SimilarityA key...
226
Critical Thinking I01:24

Critical Thinking I

5.2K
Critical thinking helps decision-making and allows nurses to recognize barriers to success and find solutions to possible issues. It helps to brainstorm and implement ideas to achieve goals. Critical thinking helps acknowledge and state workflow inefficiencies while improving management techniques. Nurses understand the value of critical thinking and look for fellow nurses with critical thinking skills to upgrade their professional standards. Critical thinking can advance a nurse's career...
5.2K
Critical Thinking II01:25

Critical Thinking II

4.7K
Critical thinking is a cognitive process with several attributes. The attributes of critical thinking include the following:
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unstressed cells are alike, but stressed cells differ: Environmental and single-cell heterogeneity in yeast stress responses.

bioRxiv : the preprint server for biology·2026
Same author

Environment-by-Environment Interactions Differ Across Genetic Backgrounds.

Molecular biology and evolution·2025
Same author

Asymmetric development and function of paired sperm-storage organs in <i>Drosophila melanogaster</i>.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Epistasis and cryptic QTL identified using modified bulk segregant analysis of copper resistance in budding yeast.

Genetics·2025
Same author

2024 Zuckerkandl Prize.

Journal of molecular evolution·2025
Same author

Epistasis and cryptic QTL identified using modified bulk segregant analysis of copper resistance in budding yeast.

bioRxiv : the preprint server for biology·2024
Same journal

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same journal

Conserved machinery, divergent functions: evolutionary plasticity of the STK36/ULK4 kinase complex in ciliogenesis and signaling.

Seminars in cell & developmental biology·2026
Same journal

Chemical biology tools for studying tissue development.

Seminars in cell & developmental biology·2026
Same journal

Tetrahymena as a model organism for cilia research.

Seminars in cell & developmental biology·2026
Same journal

Emerging Concepts in Cardiovascular Development and Regeneration.

Seminars in cell & developmental biology·2026
Same journal

Endothelial origin of hematopoietic stem cells: Insights from new technologies and unresolved questions.

Seminars in cell & developmental biology·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
03:52

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

10.9K

Decanalizing thinking on genetic canalization.

Kerry Geiler-Samerotte1, Federica M O Sartori2, Mark L Siegal2

  • 1Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, 10003, United States; Department of Biology, Stanford University, Stanford, CA, 94305-5020, United States.

Seminars in Cell & Developmental Biology
|May 12, 2018
PubMed
Summary
This summary is machine-generated.

Genetic canalization, where systems evolve to resist mutation effects, is challenged by new findings. Gene products can both buffer and potentiate mutation impacts, questioning complex trait evolution theories.

Keywords:
BufferingCanalizationEpistasisEvolution of complex traitsGene-regulatory networksPotentiation

More Related Videos

Testing of all Six Semicircular Canals with Video Head Impulse Test Systems
08:38

Testing of all Six Semicircular Canals with Video Head Impulse Test Systems

Published on: April 18, 2019

32.8K
Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
17:50

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Published on: July 4, 2007

13.0K

Related Experiment Videos

Last Updated: Feb 10, 2026

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
03:52

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

10.9K
Testing of all Six Semicircular Canals with Video Head Impulse Test Systems
08:38

Testing of all Six Semicircular Canals with Video Head Impulse Test Systems

Published on: April 18, 2019

32.8K
Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
17:50

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Published on: July 4, 2007

13.0K

Area of Science:

  • Evolutionary Biology
  • Genetics
  • Systems Biology

Background:

  • Genetic canalization posits that evolved systems minimize sensitivity to mutations.
  • This concept influences understanding of complex trait evolution and disease treatment strategies.
  • Recent evidence challenges the expected outcomes when canalization agents are impaired.

Purpose of the Study:

  • To review evidence for gene products as agents of genetic canalization.
  • To identify potential errors in inferring canalization.
  • To investigate the dual role of gene products as buffers or potentiators of mutation effects.

Main Methods:

  • Review of existing evidence on genetic canalization.
  • Analysis of gene product interactions with mutations.
  • Exploration of simulated gene-regulatory networks.

Main Results:

  • Inferences about canalization agents may involve a converse error.
  • Candidate canalization agents can increase or decrease phenotypic impacts of different mutations.
  • Simulated gene products also exhibit variable buffering and potentiation effects.

Conclusions:

  • The role of a gene product as a buffer or potentiator is mutation-specific, not fixed.
  • The extent to which complex traits are canalized against genetic change is questionable.
  • Further research is needed to understand genetic interactions and their impact on evolution.