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The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study

Radmila Karan1,2, Biljana Obrenovic-Kircanski3,4, Suzana Cvjeticanin5,6

  • 1Faculty of Medicine, University of Belgrade, Koste Todorovic 8, Belgrade 11000, Serbia. karan.radmila@gmail.com.

Journal of Clinical Medicine
|May 13, 2018
PubMed

Insights

Genetic analysis reveals increased homozygosity and reduced variability in coronary artery disease (CAD) patients compared to controls. This suggests a potential genetic predisposition for developing CAD in both males and females.

Area of Science:

  • Genetics
  • Cardiology
  • Human Physiology

Background:

  • Coronary artery disease (CAD) is a multifactorial condition influenced by genetic and environmental factors.
  • Understanding genetic predispositions can aid in risk stratification and prevention strategies.
  • Morphogenetic variability and homozygosity are potential indicators of genetic health and disease susceptibility.

Purpose of the Study:

  • To investigate the association between genetic homozygosity and coronary artery disease (CAD).
  • To compare the degree of recessive homozygosity and morphogenetic variability between CAD patients and healthy controls.
  • To explore potential gender-specific differences in these genetic markers in relation to CAD.

Main Methods:

  • Analyzed morphogenetic variability and homozygosity using the homozygously recessive characteristics (HRC) test in 235 CAD patients and 152 healthy controls.
  • Tested 19 specific HRCs to quantify the degree of recessive homozygosity.
  • Compared HRC frequencies between CAD patients (with and without diabetes mellitus or hypertension) and control groups, analyzing data separately for males and females.

Main Results:

  • CAD patients exhibited a significantly higher frequency of HRCs compared to controls in both males (p < 0.001) and females (p < 0.001).
  • This significant difference persisted when comparing controls to CAD patients with diabetes mellitus (DM) and hypertension (HTN).
  • No significant difference in HRC frequencies was observed between CAD with DM and CAD with HTN groups.

Conclusions:

  • Findings indicate an increased degree of recessive homozygosity and decreased variability in both genders of CAD patients.
  • This suggests a potential genetic predisposition contributing to the development of coronary artery disease.
  • Genetic factors, specifically homozygosity, may play a significant role in CAD susceptibility.

Keywords:
coronary artery diseasegenderhomozygous recessive characteristicsvariability

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