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In Vitro and In Vivo SERS Biosensing for Disease Diagnosis
T Joshua Moore1, Amber S Moody2, Taylor D Payne3
1Department of Chemistry, The University of Tennessee, 1420 Circle Drive, Knoxville, TN 37996, USA. tmoore56@vols.utk.edu.
Biosensors
|May 13, 2018
Summary
Early disease diagnosis is key for effective treatment. Surface-enhanced Raman spectroscopy (SERS) offers sensitive, label-free detection of diseases like cancer and diabetes through enhanced Raman scattering signals.
Area of Science:
- Biomedical Engineering
- Spectroscopy
- Biosensing
Background:
- Early disease diagnosis significantly improves patient outcomes and treatment efficacy.
- Label-free sensing techniques are crucial for detecting low analyte concentrations in physiological samples.
- Surface-enhanced Raman spectroscopy (SERS) provides highly sensitive and selective analyte detection.
Purpose of the Study:
- To review recent advancements in in vivo and in vitro SERS biosensing.
- To highlight the application of SERS in diagnosing various diseases.
- To showcase SERS as a promising diagnostic tool.
Main Methods:
- Utilizing plasmonic materials to amplify localized electric fields.
- Employing monochromatic light excitation to enhance Raman scattering signals.
- Reviewing studies on SERS for neurological, diabetic, cardiovascular, cancer, and viral diseases.
Main Results:
- SERS enables label-free, sensitive, and selective detection of low-concentration analytes.
- Demonstrated SERS's utility across a spectrum of disease states.
- Highlighted the potential of SERS for in vivo and in vitro diagnostics.
Conclusions:
- SERS is a powerful tool for early disease detection.
- Recent developments show significant promise for SERS in clinical diagnostics.
- SERS biosensing is advancing the field of disease diagnosis.
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