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Published on: May 20, 2019
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Protective Effects of Selected Botanical Agents on Bone
James Jam Jolly1, Kok-Yong Chin2, Ekram Alias3
1Department of Pharmacology, Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Wilayah Persekutuan Kuala Lumpur, Malaysia. jamesjamjolly@yahoo.com.my.
Summary
Herbal plants show promise for preventing osteoporosis by protecting bone health. Further clinical research is needed to confirm their anti-osteoporotic effects and potential use alongside conventional treatments.
Area of Science:
- Pharmacology
- Herbal Medicine
- Bone Biology
Background:
- Osteoporosis affects over 200 million elderly globally, causing bone loss and fractures.
- Early symptoms are often undetectable, leading to significant morbidity, mortality, and healthcare costs.
- Herbal medicine contains bioactive compounds with potential skeletal protective effects.
Purpose of the Study:
- To explore the anti-osteoporotic properties of selected herbal plants.
- To investigate their mechanisms of action on bone cells and remodeling.
- To discuss their pharmaceutical applications.
Main Methods:
- Literature review of herbal plants with anti-osteoporotic potential.
- Analysis of actions on osteoblasts and osteoclasts.
- Examination of bone remodeling effects.
Main Results:
- Selected herbal families (Berberidaceae, Fabaceae, Arecaceae, Labiatae, Simaroubaceaea, Myrsinaceae) possess anti-osteoporotic properties.
- Active constituents and mechanisms of action were discussed.
- Limited human clinical trials exist for these herbal therapies.
Conclusions:
- Herbal plants offer potential in osteoporosis management.
- More intensive research and clinical trials are required.
- Herbal therapies could complement conventional osteoporosis drugs.
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