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Updated: Feb 10, 2026
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes
Phennapha Saokham1, Chutimon Muankaew2, Phatsawee Jansook3
1Faculty of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand. phennapha.s@rsu.ac.th.
Molecules (Basel, Switzerland)
|May 13, 2018
Summary
Cyclodextrins (CDs) form complexes with drugs to improve properties. Optimizing CD use in formulations is key, considering excipient interactions and solubility challenges.
Area of Science:
- Pharmaceutical Sciences
- Supramolecular Chemistry
Background:
- Cyclodextrins (CDs) are glucose-unit oligosaccharides forming ring structures.
- CDs can complex with drug molecules, enhancing physicochemical properties without altering drug structure.
- Natural CDs tend to aggregate in water, limiting their solubility and effectiveness.
Purpose of the Study:
- To explore the potential of cyclodextrins (CDs) in pharmaceutical formulations.
- To understand how CD derivatives and excipients influence drug complexation and solubility.
- To optimize the use of CDs for enhanced drug permeation through biological membranes.
Main Methods:
- Review of cyclodextrin complexation principles.
- Analysis of factors affecting CD solubility and aggregation.
- Consideration of drug-CD stoichiometry and excipient interactions in formulation.
Main Results:
- CD complexation can improve drug properties, with 1:1 stoichiometry being common.
- CD derivatives offer enhanced solubility and complexation capacity.
- Excipients can influence CD solubilizing abilities, necessitating consideration of competitive complexation.
Conclusions:
- Optimizing cyclodextrin (CD) concentration in pharmaceutical preparations is crucial for maximizing drug permeation.
- Understanding the interplay between CDs, drugs, and excipients is essential for successful formulation development.
- Derivative formation and careful excipient selection can overcome solubility limitations of CDs.
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