Preoperative 6-Minute Walk Distance Is Associated With Postoperative Cognitive Dysfunction.

Area of Science:

• Cardiology
• Neurology
• Geriatrics

Background:

• Postoperative cognitive dysfunction (POCD) is a significant neurologic issue affecting patients for weeks to months after surgery.
• The 6-minute walk distance (6MWD) is a known predictor of postoperative complications.
• Identifying preoperative risk factors for POCD is crucial for patient management.

Purpose of the Study:

• To investigate the association between preoperative 6-minute walk distance (6MWD) and the development of postoperative cognitive dysfunction (POCD).
• To determine if a low preoperative 6MWD is an independent risk factor for POCD in patients undergoing cardiac operations.

Main Methods:

• 181 patients undergoing cardiac operations were prospectively assessed.
• Preoperative 6-minute walk distance (6MWD) was measured.
• Postoperative cognitive dysfunction (POCD) was defined as a ≥2-point decrease in Mini-Mental State Examination score.
• Multivariable logistic regression analysis identified risk factors.

Main Results:

• POCD developed in 28% of patients (51 out of 181).
• Patients with POCD had a significantly lower median 6MWD (400m) compared to those without POCD (450m).
• Low 6MWD, longer ICU stay, older age, and lower MMSE scores were independent risk factors for POCD.

Conclusions:

• The 6-minute walk distance (6MWD) is a valuable tool for predicting the likelihood of developing postoperative cognitive dysfunction (POCD) after cardiac surgery.
• Preoperative 6MWD can aid in identifying high-risk patients for POCD.