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Testosterone and Sarcopenia.

Myung Jun Shin1,2, Yun Kyung Jeon3,4, In Joo Kim3,2

  • 1Department of Rehabilitation Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

The World Journal of Men'S Health
|May 15, 2018
PubMed
Summary

Aging leads to muscle loss and fat gain, increasing sarcopenia risk. Testosterone decline contributes to these changes, and testosterone therapy may help, though results vary. Further research is needed.

Keywords:
AgingBody compositionMusclesSarcopeniaTestosterone

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Area of Science:

  • Gerontology
  • Endocrinology
  • Metabolism

Background:

  • Aging is associated with metabolic changes, including reduced skeletal muscle mass and increased body fat.
  • Sarcopenia, the age-related loss of muscle mass and strength, is linked to these body composition changes.
  • Declining testosterone levels in aging men correlate with unfavorable body composition and may contribute to sarcopenia.

Purpose of the Study:

  • To discuss the relationship between testosterone levels and muscle mass/function in aging.
  • To examine the impact of testosterone on sarcopenia.
  • To explore potential mechanisms linking testosterone to muscle health.

Main Methods:

  • Literature review and synthesis of existing research on testosterone, aging, body composition, and sarcopenia.
  • Analysis of studies investigating the effects of testosterone treatment on muscle mass and function.
  • Discussion of potential biological pathways involved.

Main Results:

  • Low testosterone is associated with decreased muscle mass and increased fat mass.
  • Testosterone deficiency is a potential modifiable factor in sarcopenia development.
  • Evidence for testosterone's efficacy in improving muscle mass and function is inconsistent across studies.

Conclusions:

  • Testosterone plays a role in maintaining muscle mass and function during aging.
  • Androgen deficiency may be a contributing factor to sarcopenia.
  • Further research is warranted to clarify the role and optimize the use of testosterone therapy for sarcopenia.