Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microcracking in Concrete01:20

Microcracking in Concrete

480
Microcracking in concrete refers to the tiny cracks that can form within the material even before any external load is applied. These microcracks typically occur at the interface between the coarse aggregate and the hydrated cement paste, often as a result of differential volume changes prompted by variations in stress-strain behavior, as well as thermal and moisture movement. Initially, these microcracks remain stable and do not grow substantially until the concrete is stressed to about 30...
480
The Carbon Cycle01:14

The Carbon Cycle

44.0K
Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle.
44.0K
Carbon Skeletons01:12

Carbon Skeletons

115.5K
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
115.5K
The Dot Product01:26

The Dot Product

266
Measuring how one directional quantity affects another along a specific path involves comparing their orientation and strength. When two such quantities are represented using direction and amount, a numerical result is computed to show how much one acts along the path of the other. This result comes from a rule combining both inputs' horizontal and vertical parts and adding the results.This calculation gives a single value that grows larger when both inputs point in similar directions and...
266
Dot Product01:29

Dot Product

1.0K
The dot product is an essential concept in mathematics and physics.
In engineering, the dot product of any two vectors is the product of the magnitudes of the vectors and the cosine of the angle between them. It is denoted by a dot symbol between the two vectors.
Consider a vehicle pulling an object along the ground using a rope. If the rope makes an angle with the horizontal axis, the work done can be calculated using the dot product of the force applied and the object's displacement.
The dot...
1.0K
Dot Product: Problem Solving01:21

Dot Product: Problem Solving

721
The dot product is a powerful tool in problem-solving involving vectors, given that the dot product of two vectors is the product of their magnitudes and the cosine of the angle between them measured anti-clockwise. Solving problems involving the dot product requires understanding its properties and developing a step-by-step process to solve them. Here are the main steps to follow when solving any general problem involving the dot product:
Identify the problem: Start by reading the problem and...
721

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining and quantifying oxygen delivery potency of blood products.

Blood. Red cells & iron·2026
Same author

A Dual-Pronged Hafnia-Prodrug-Lipid Nanoplatform Coupling Radiosensitization and DNA Homologous Recombination Inhibition.

ACS nano medicine·2026
Same author

Surface Passivated Nanocarbon Generates a Phase-Separated Hydrogel Meshwork for Skeletal Muscle Tissue Engineering.

ACS biomaterials science & engineering·2026
Same author

A clade-specific, amplification-free molecular lateral flow platform for on-site detection of Mpox.

Chemical communications (Cambridge, England)·2026
Same author

Liposome-Encapsulated Carfilzomib as a Radiosensitizer in Solid Tumors.

Molecular pharmaceutics·2026
Same author

Catalytic Wiring of Enzymatic Cascades Using ROS-Flux-Regulated Biodegradable Borophene.

Small (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Feb 10, 2026

Resonance Fluorescence of an InGaAs Quantum Dot in a Planar Cavity Using Orthogonal Excitation and Detection
12:57

Resonance Fluorescence of an InGaAs Quantum Dot in a Planar Cavity Using Orthogonal Excitation and Detection

Published on: October 13, 2017

9.6K

Fluorescence Detection of Bone Microcracks Using Monophosphonated Carbon Dots.

Fatemeh Ostadhossein1, Lily Benig1, Indu Tripathi1

  • 1Department of Bioengineering , University of Illinois at Urbana-Champaign , Urbana , Illinois 61801 , United States.

ACS Applied Materials & Interfaces
|May 15, 2018
PubMed
Summary

Researchers developed novel phosphonated carbon dots (CDs) for bone imaging. These luminescent nanoparticles exhibit strong bone mineral binding, enabling visualization of microcracks and offering potential for future bone therapies.

Keywords:
bone imagingcarbon dotfluorescencein vivophosphonated compounds

More Related Videos

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging
06:19

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging

Published on: June 9, 2023

2.1K
Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays
07:13

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays

Published on: June 28, 2024

2.2K

Related Experiment Videos

Last Updated: Feb 10, 2026

Resonance Fluorescence of an InGaAs Quantum Dot in a Planar Cavity Using Orthogonal Excitation and Detection
12:57

Resonance Fluorescence of an InGaAs Quantum Dot in a Planar Cavity Using Orthogonal Excitation and Detection

Published on: October 13, 2017

9.6K
Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging
06:19

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging

Published on: June 9, 2023

2.1K
Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays
07:13

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays

Published on: June 28, 2024

2.2K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Medical Imaging

Background:

  • Phosphonated compounds, especially bisanalogs, are crucial in treating bone disorders and serve as imaging agents.
  • Organic fluorophore conjugation is a common method for creating bone-targeting imaging probes.

Purpose of the Study:

  • To develop a novel, bone-seeking luminescent probe with high affinity for bone minerals.
  • To investigate the potential of monophosphonated carbon dots (CDs) as standalone imaging agents for bone applications.

Main Methods:

  • Synthesis of spheroidal carbon dots (CDs) tethered with PEG monophosphates via a one-pot hydrothermal method.
  • Physicochemical characterization including 13P NMR and X-ray photoelectron spectroscopy to confirm phosphonate retention.
  • Evaluation of binding affinity to hydroxyapatite and imaging feasibility in ex vivo bovine cortical bone models.

Main Results:

  • Monophosphonated CDs demonstrated strong binding to hydroxyapatite due to abundant monodentate phosphonates.
  • Successful imaging of microcracks in ex vivo bone models was achieved.
  • In vivo studies indicated potential for intramuscular imaging applications.

Conclusions:

  • Monophosphonated CDs offer a nanoscale strategy for bone targeting and imaging without requiring secondary fluorophores.
  • The probe exhibits biodegradability and cytocompatibility, paving the way for future bone therapeutic applications.