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Updated: Feb 10, 2026
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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
Published on: January 15, 2013
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A handheld microscope integrating photoacoustic microscopy and optical coherence tomography
Wei Qin1,2, Qian Chen1,2, Lei Xi1,2
1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
Biomedical Optics Express
|May 16, 2018
Summary
We developed a compact, handheld dual-modality microscope combining optical resolution photoacoustic microscopy (ORPAM) and optical coherence tomography (OCT). This miniaturized system enables complementary imaging for potential clinical applications.
Area of Science:
- Biomedical Engineering
- Optical Imaging
- Microscopy
Background:
- Combining optical resolution photoacoustic microscopy (ORPAM) and optical coherence tomography (OCT) offers complementary imaging contrasts.
- Miniaturizing ORPAM for handheld dual-modality OCT systems presents significant engineering challenges.
Purpose of the Study:
- To design and evaluate an integrated ORPAM and OCT imaging probe.
- To overcome miniaturization challenges for handheld dual-modality microscopy.
Main Methods:
- Utilized a two-dimensional MEMS (micro-electro-mechanical-system)-based optical scanner for probe integration.
- Developed an ultracompact microscope with dimensions of 65×30×18 mm³ and a weight of 35.4 g.
Main Results:
- Achieved experimental lateral resolutions of 3.7 μm (ORPAM) and 5.6 μm (OCT).
- Measured axial resolutions of 120 μm (ORPAM) and 7.3 μm (OCT).
- Demonstrated clinical feasibility through oral imaging of a healthy volunteer.
Conclusions:
- The developed MEMS-based probe successfully integrates ORPAM and OCT in a miniaturized form factor.
- The dual-modality microscope shows potential for in-vivo applications, evidenced by successful oral imaging.
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