Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains
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Updated: Feb 10, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
Published on: September 23, 2021
Miguel Arbesú1, Guillermo Iruela1, Héctor Fuentes1
1BioNMR Laboratory, Inorganic and Organic Chemistry Department, University of Barcelona, Barcelona, Spain.
Abstract:
Structural disorder is an essential ingredient for function in many proteins and protein complexes. Fuzzy complexes describe the many instances where disorder is maintained as a critical element of protein interactions. In this minireview we discuss how intramolecular fuzzy interactions function in signaling complexes. Focussing on the Src family of kinases, we argue that the intrinsically disordered domains that are unique for each of the family members and display a clear fingerprint of long range interactions in Src, might have critical roles as functional sensor or effectors and mediate allosteric communication via fuzzy interactions.
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