Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

353
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
353
Harmonic Mean01:09

Harmonic Mean

3.8K
The arithmetic mean is usually skewed towards the larger values in the data set. Therefore, to avoid this inherent bias towards smaller values, the harmonic mean is used.
Take the example of the speed of a car, which is the measure of the rate of distance traveled. If the vehicle traverses the same distance back-and-forth, its average speed equals the total distance traveled divided by the total time taken. However, if the car moves with varying speeds, then the arithmetic mean is more skewed...
3.8K
Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

Nonlinear Pharmacokinetics: Causes of Nonlinearity

744
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
744
Diffusion01:12

Diffusion

221.5K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
221.5K
Limiting Reactant02:27

Limiting Reactant

70.4K
The relative amounts of reactants and products represented in a balanced chemical equation are often referred to as stoichiometric amounts. However, in reality, the reactants are not always present in the stoichiometric amounts indicated by the balanced equation.
70.4K
The Number e as a Limit01:29

The Number e as a Limit

99
The number e is a fundamental constant in calculus, playing a central role in describing continuous change, particularly exponential growth. It is most naturally defined through its relationship with the natural logarithm, which is the inverse of the exponential function with base e. This relationship allows e to be characterized using basic principles of differentiation rather than as an arbitrary numerical constant.A key property of the natural logarithm function, ln x, is that its derivative...
99

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Critical factors influencing the adoption of virtual reality technology for improving mental health among university students: an extended technology acceptance model.

Frontiers in psychology·2026
Same author

Cold Disinfestation of <i>Zeugodacus tau</i> (Diptera: Tephritidae) on Oranges Using Artificial Infestation Method.

Insects·2026
Same author

In situ expansion capacity evaluation of terminal alveoli in chronic obstructive pulmonary disease using an ultrathin optical coherence tomography catheter.

Biomedical optics express·2026
Same author

Large-scale transparent photoacoustic cranial window for long-term whole-brain cortical imaging.

Optics letters·2025
Same author

Red light promotes dermis-epidermis remodeling via TGFβ and AKT-mediated collagen dynamics in naturally aging mice.

Zoological research·2025
Same author

GCSA-SegFormer: Transformer-Based Segmentation for Liver Tumor Pathological Images.

Bioengineering (Basel, Switzerland)·2025
Same journal

Gaussian-modulated continuous-variable quantum key distribution over 60 km fiber using an integrated silicon photonic receiver.

Optics letters·2026
Same journal

E2E-OCT: end-to-end joint learning model using optical coherence tomography images for vocal cord leukoplakia diagnosis.

Optics letters·2026
Same journal

Holographic generation of panoramic 3D scenes by concave ellipsoidal mirror reflection.

Optics letters·2026
Same journal

Dual-pilot phase recovery with pair-wise maximum-ratio combining for coherent PONs.

Optics letters·2026
Same journal

Mapping the whispering gallery modes of a CaF<sub>2</sub> disk resonator with half-tapered fibers to estimate the fundamental mode volume.

Optics letters·2026
Same journal

Quantitative estimation of deep-subwavelength scale via dark-field scattering axial energy concentration decay profiles.

Optics letters·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Three-dimensional Optical-resolution Photoacoustic Microscopy
08:31

Three-dimensional Optical-resolution Photoacoustic Microscopy

Published on: May 3, 2011

18.9K

Subdiffraction-limited second harmonic photoacoustic microscopy based on nonlinear thermal diffusion.

Zhenhui Zhang, Yujiao Shi, Sihua Yang

    Optics Letters
    |May 16, 2018
    PubMed
    Summary
    This summary is machine-generated.

    We developed second harmonic photoacoustic microscopy (SH-PAM) for super-resolution imaging. This nonlinear thermal diffusion method achieves subdiffraction-limited resolution, surpassing conventional photoacoustic microscopy for biological and material inspection.

    More Related Videos

    Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy
    09:19

    Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy

    Published on: August 29, 2025

    630
    Harmonic Nanoparticles for Regenerative Research
    09:23

    Harmonic Nanoparticles for Regenerative Research

    Published on: May 1, 2014

    12.1K

    Related Experiment Videos

    Last Updated: Feb 10, 2026

    Three-dimensional Optical-resolution Photoacoustic Microscopy
    08:31

    Three-dimensional Optical-resolution Photoacoustic Microscopy

    Published on: May 3, 2011

    18.9K
    Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy
    09:19

    Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy

    Published on: August 29, 2025

    630
    Harmonic Nanoparticles for Regenerative Research
    09:23

    Harmonic Nanoparticles for Regenerative Research

    Published on: May 1, 2014

    12.1K

    Area of Science:

    • Biomedical Optics
    • Photoacoustic Imaging
    • Super-resolution Microscopy

    Background:

    • Conventional photoacoustic microscopy (PAM) is limited by optical resolution.
    • Developing super-resolution techniques is crucial for advanced biological imaging.

    Purpose of the Study:

    • To develop a novel second harmonic photoacoustic microscopy (SH-PAM) technique.
    • To achieve subdiffraction-limited imaging using nonlinear thermal diffusion.

    Main Methods:

    • Utilized a sine-modulated Gaussian laser beam to induce a temperature field.
    • Exploited the temperature dependence of thermal diffusivity for nonlinear photoacoustic (PA) signal generation.
    • Reconstructed second harmonic PA images through simulation and experimental validation.

    Main Results:

    • Demonstrated lateral resolution exceeding conventional optical resolution PA microscopy.
    • Verified the feasibility of SH-PAM on phantom samples.
    • Successfully imaged Amphioxus zygotes and germinated pollens.

    Conclusions:

    • SH-PAM offers a viable method for super-resolution imaging.
    • This technique expands the capabilities of conventional PA imaging.
    • SH-PAM shows significant potential for high-resolution biological imaging and material inspection.