Related Experiment Video

Updated: Feb 10, 2026

A Nonsequencing Approach for the Rapid Detection of RNA Editing
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A Nonsequencing Approach for the Rapid Detection of RNA Editing

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A-to-I RNA Editing: An Overlooked Source of Cancer Mutations

Shay Ben-Aroya1, Erez Y Levanon1

  • 1The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.

Cancer Cell
|May 16, 2018
PubMed

Insights

RNA editing creates transcriptomic diversity and protein heterogeneity in cancer. This study reveals RNA editing events impact protein levels, contributing to cancer

Area of Science:

  • Molecular biology
  • Genomics
  • Cancer research

Background:

  • RNA editing contributes to transcriptomic diversity, primarily in non-coding RNA regions.
  • Alterations in RNA editing are observed in various cancer types.

Purpose of the Study:

  • To investigate the manifestation of RNA editing at the proteomic level.
  • To explore RNA editing as a source of protein heterogeneity in cancer.

Main Methods:

  • Proteomic analysis
  • RNA sequencing
  • Bioinformatic analysis of RNA editing events

Main Results:

  • RNA editing events were detected at the proteomic level.
  • Significant correlation between RNA editing and protein expression profiles in cancer.

Conclusions:

  • RNA editing contributes to cancer protein heterogeneity.
  • Understanding RNA editing's proteomic impact is crucial for cancer research.

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