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Related Concept Videos

Lewis Acids and Bases02:33

Lewis Acids and Bases

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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
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Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
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Base Excision Repair01:54

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
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Ions as Acids and Bases02:54

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Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
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DNA Base Pairing02:27

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Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
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Bronsted-Lowry Acids and Bases02:58

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The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
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[Registry-based research in ophthalmology].

J Li1, C Heinz2,3, R P Finger4

  • 1Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|May 17, 2018
PubMed
Summary
This summary is machine-generated.

Medical registries provide valuable real-world data, especially for rare diseases like childhood uveitis. These studies improve health services and inform treatment guidelines for better patient outcomes.

Keywords:
Health care researchJuvenile idiopathic arthritisRare diseasesRegistriesUveitis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Health Services Research

Background:

  • Medical registries capture real-world data valuable for health services research.
  • Registry studies are crucial for rare diseases where traditional studies are challenging.
  • Few ophthalmological registries exist, highlighting a data gap.

Purpose of the Study:

  • To discuss the benefits of medical registries using non-infectious uveitis in juvenile idiopathic arthritis (JIA) as an example.
  • To emphasize the need for data on treatment, outcomes, and risk factors in pediatric uveitis.
  • To advocate for the development of ophthalmological registries.

Main Methods:

  • Utilizing a registry with a uveitis module to gather data on non-infectious uveitis in children and adolescents with JIA.
  • Leveraging existing registry data to derive scientific publications and clinical guidelines.
  • Analyzing real-world data to understand disease progression and treatment efficacy.

Main Results:

  • Registry data has proven advantageous for studying non-infectious uveitis in JIA.
  • Successful registries have contributed to epidemiological research and improved health service delivery.
  • The example demonstrates the potential of registries to generate publications and guidelines.

Conclusions:

  • Medical registries are essential tools for advancing research and improving care in ophthalmology, particularly for rare conditions.
  • The development of specialized ophthalmological registries is needed to address data deficiencies.
  • Registries facilitate evidence-based practice and enhance understanding of disease trajectories.