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The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test
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TREMendous 2 Be Social.

Narghes Calcagno1, Caroline Baufeld1, Charlotte Madore1

  • 1Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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Summary
This summary is machine-generated.

Microglial TREM2 (triggering receptor expressed on myeloid cells 2) is crucial for synaptic pruning during early development. TREM2 deficiency in mice leads to altered social behavior, suggesting a role in neurodevelopmental disorders.

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Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Triggering receptor expressed on myeloid cells 2 (TREM2) is primarily known for its function in microglial phagocytosis.
  • TREM2 is implicated in various neurodegenerative diseases.

Purpose of the Study:

  • To investigate the role of microglial TREM2 in early neurodevelopment.
  • To explore the consequences of TREM2 deficiency on brain function and behavior.

Main Methods:

  • Utilized TREM2-deficient mouse models.
  • Assessed synaptic pruning during early developmental stages.
  • Evaluated social behavior in adult mice.

Main Results:

  • Microglial TREM2 is essential for proper synaptic pruning in early development.
  • TREM2-deficient mice exhibit abnormal social behavior in adulthood.
  • These findings link TREM2 to neurodevelopmental processes.

Conclusions:

  • TREM2 plays a critical, previously unrecognized role in synaptic pruning.
  • Dysfunctional TREM2 may contribute to neurodevelopmental disorders with social behavior deficits.