Related Experiment Video
Updated: Feb 10, 2026
09:15
In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
1.2K
Baseline Thromboelastogram as a Predictor of Left Ventricular Assist Device Thrombosis
Shannon L Piche1, Scott D Nei1, Erin Frazee1
1From the Department of Pharmacy, Mayo Clinic, Rochester, MN.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|May 17, 2018
Summary
Thromboelastography (TEG) maximum amplitude (MA) hypercoagulability at left ventricular assist device (LVAD) implantation did not predict pump thrombosis in this study. This novel concept showed no significant association between baseline TEG-MA and LVAD thrombosis risk.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Medical Devices
Background:
- Left ventricular assist device (LVAD) pump thrombosis is a significant complication, occurring in up to 8.4% of patients within 3 months.
- Thromboelastography (TEG) measures blood coagulation and may identify hypercoagulable states.
- Hypercoagulability at LVAD implantation could potentially predict the risk of subsequent pump thrombosis.
Purpose of the Study:
- To evaluate if TEG maximum amplitude (MA) hypercoagulability (MA ≥69 mm) at LVAD implantation predicts LVAD pump thrombosis.
- To investigate the association between baseline TEG-MA and the risk of device thrombosis.
Main Methods:
- A retrospective, nested case-control study included 111 participants (37 case-control sets) from 2005 to 2015.
- Cases with LVAD pump thrombosis were matched to two controls based on age, sex, and follow-up duration.
- Multivariable logistic regression analysis calculated the odds ratio (OR) and 95% confidence interval (CI) for the association between TEG-MA hypercoagulability and thrombosis.
Main Results:
- TEG-MA hypercoagulability was observed in 10.8% of the thrombosis case group and 6.8% of the control group.
- No significant association was found between TEG-MA hypercoagulability at LVAD implantation and the occurrence of LVAD pump thrombosis (OR 1.71, 95% CI 0.42-7.05, p = 0.46).
Conclusions:
- Baseline TEG-MA hypercoagulability does not appear to be a reliable predictor of LVAD pump thrombosis.
- Further research may be needed to identify effective biomarkers for predicting LVAD thrombosis risk.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
478
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
478
01:29Venous Thrombosis III: Interprofessional Care
378
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
378
01:30Venous Thrombosis IV: Nursing Management
269
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
269
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
352
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
352
01:23Mnemonic Devices
444
Mnemonic devices are cognitive tools that facilitate memory retention by linking new information to familiar patterns or organizational strategies. These techniques are beneficial for remembering complex or lengthy sets of information by simplifying and structuring them in easily retrievable ways.
Acronyms
Acronyms are created by using the initial letters of a series of words to form a new word or phrase. This approach condenses complex information into a single, memorable entity. For example,...
Acronyms
Acronyms are created by using the initial letters of a series of words to form a new word or phrase. This approach condenses complex information into a single, memorable entity. For example,...
444
00:51Non-ohmic Devices
1.5K
In most substances, the current flow is proportional to the voltage applied to it. A simple relationship between the values of current, voltage, and resistance is known as Ohm's law. Nonohmic devices do not exhibit a linear relationship between voltage and current. One such device is the semiconducting circuit element known as a diode. A diode is a circuit device that allows current flow in only one direction.
Consider a simple circuit consisting of a battery, a diode, and a resistor. A...
Consider a simple circuit consisting of a battery, a diode, and a resistor. A...
1.5K