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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Therapies for mobility disability in persons with multiple sclerosis.

Jessica F Baird1,2, Brian M Sandroff1,2, Robert W Motl1,2

  • 1a Department of Physical Therapy , University of Alabama at Birmingham , Birmingham , AL , USA.

Expert Review of Neurotherapeutics
|May 18, 2018
PubMed
Summary

This review explores treatments for multiple sclerosis (MS) mobility disability. While disease-modifying drugs slow progression, symptomatic therapies like dalfampridine and non-pharmacologic approaches are key for improving walking function.

Keywords:
Dalfampridineexercise traininggait trainingmobility disabilitymultiple sclerosisphysical therapywalking

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Area of Science:

  • Neurology
  • Rehabilitation Medicine

Background:

  • Mobility disability is a significant challenge for individuals with multiple sclerosis (MS).
  • Disease-modifying drugs (DMDs) primarily slow MS progression, with limited evidence for reversing mobility impairments.
  • Current treatments focus on managing symptoms to improve ambulatory function.

Purpose of the Study:

  • To review symptomatic pharmacologic and non-pharmacologic therapies for mobility disability in MS.
  • To evaluate the efficacy of treatments aimed at restoring and improving walking function.
  • To provide guidance for future research directions in MS mobility.

Main Methods:

  • Review of existing literature on pharmacologic and non-pharmacologic interventions for MS-related mobility issues.
  • Analysis of the efficacy of dalfampridine, a FDA-approved symptomatic treatment for MS walking impairment.
  • Examination of non-pharmacologic therapies including exercise, physical therapy, and gait training.

Main Results:

  • Dalfampridine is the only FDA-approved symptomatic drug shown to improve walking in MS patients.
  • Non-pharmacologic therapies such as exercise, physical therapy, and gait training also demonstrate efficacy in enhancing walking function.
  • Combinatory and multidisciplinary approaches are likely essential for optimal outcomes.

Conclusions:

  • Symptomatic treatments are crucial for addressing mobility disability in MS.
  • Further research is needed to establish the efficacy of rehabilitative strategies, both individually and in combination.
  • A comprehensive, multidisciplinary approach is recommended for managing MS-related mobility impairments.