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Nanocrystals Technology for Pharmaceutical Science.

Zhongyao Cheng1, Yumei Lian1, Zul Kamal1,2

  • 1School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

Current Pharmaceutical Design
|May 19, 2018
PubMed
Summary
This summary is machine-generated.

Nanocrystal technology enhances drug dissolution and bioavailability for poorly soluble medications. This review details preparation, applications, and challenges of nanocrystal drug development.

Keywords:
Nanocrystals technologydeliverymarketpoorly soluble drugsregulatoryscale-up.

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Area of Science:

  • Pharmaceutical Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Nanocrystal technology offers a significant advantage for improving the dissolution rate and bioavailability of poorly soluble drugs.
  • This technology has seen rapid development and application in drug research and engineering.
  • Nanocrystal drugs can be formulated into diverse dosage forms.

Purpose of the Study:

  • To provide a comprehensive overview of nanocrystal technology and its pharmaceutical applications.
  • To discuss various preparation methods and characterization techniques for nanocrystal drugs.
  • To explore sustained release formulations, scale-up processes, marketed products, and regulatory aspects.

Main Methods:

  • Literature review focusing on nanocrystal technology in pharmaceutical science.
  • Description of different preparation methods and characterization of nanocrystal drugs.
  • Discussion of applications, sustained release formulations, scale-up, marketed products, and regulatory considerations.

Main Results:

  • Nanocrystal technology is a key strategy for enhancing drug solubility and bioavailability.
  • Various preparation methods and characterization techniques are available for nanocrystal drug development.
  • Applications span diverse dosage forms, including sustained release formulations.

Conclusions:

  • Nanocrystal technology presents significant opportunities for pharmaceutical innovation.
  • Understanding preparation, characterization, and applications is crucial for effective drug development.
  • Addressing challenges in scale-up and regulation will further advance nanocrystal-based therapeutics.