[Clinical study on serum 25(OH)D level in patients with moderate to severe allergic rhinitis]

Objective:Through the detection of the serum 25 (OH) D level of patients with moderate to severe allergic rhinitis (AR), we preliminarily explored the mechanism of vitamin D on AR and provided evidence for the control of AR. Method:Eighty cases of moderate to severe AR and 65 healthy adults were selected as the subjects. The level of 25 (OH) D was detected by enzyme-linked immunosorbent assay (ELISA), and the serum 25 (OH) D level of eight common serum allergens in patients with moderate to severe AR was analyzed. Result:The level of serum 25 (OH) D of AR group was (29.4±4.7)ng/ml, and the serum level of 25 (OH) D in the control group was (30.9±5.9)ng/ml, no significant difference (P>0.05). The percentage of serum vitamin D deficiency in AR group was 36%, and the control group was 7%, and the difference was statistically significant (P<0.05). Among eight common serum allergens, the AR patients who were allergic to ragweed, household dust mites and shrimps, the percentage of vitamin D deficiency and insufficient was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion:Vitamin D deficiency may be associated with moderate to severe AR patients, and vitamin D may have potential beneficial effects on the progression of AR.