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Updated: Feb 10, 2026
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire
Ilse M Nauta1, Lisanne J Balk1, Judith M Sonder1
1Department of Neurology, Amsterdam Neuroscience, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Background:
Cognitive problems are difficult to identify in patients with multiple sclerosis (MS).
Objective:
To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P).
Methods:
Cut-off scores were determined to differentiate between cognitively impaired (n = 90), mildly cognitively impaired (n = 115), and cognitively preserved (n = 147) MS patients using receiver operating characteristic analyses.
Results:
We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition.
Conclusion:
Certain scores can indicate intact or impaired cognitive function. Still, MSNQ-P scores should be interpreted with caution.
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