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Clinical utility of circulating non-coding RNAs - an update
Simone Anfossi1, Anna Babayan2, Klaus Pantel3
1Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Nature Reviews. Clinical Oncology
|May 23, 2018
Summary
Circulating non-coding RNAs (ncRNAs) show promise as blood-based biomarkers for early cancer detection and monitoring. These molecules are crucial in cell communication and may indicate treatment response and resistance.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Research on circulating small and long non-coding RNAs (ncRNAs) and cancer has surged.
- ncRNAs are investigated as diagnostic and prognostic biomarkers for cancer patient management.
- Circulating ncRNAs offer potential as non-invasive, blood-based biomarkers due to their stability and abundance.
Purpose of the Study:
- To review the latest advancements in using circulating ncRNAs as diagnostic and prognostic biomarkers in cancer.
- To discuss the role of ncRNAs in cancer cell-to-cell communication.
- To compile a list of ncRNAs found in body fluids with potential as cancer biomarkers.
Main Methods:
- Literature review of studies on circulating ncRNAs in cancer.
- Analysis of ncRNA roles in intercellular communication and cancer progression.
- Compilation of reported ncRNAs in human body fluids for biomarker potential.
Main Results:
- Circulating ncRNAs are increasingly recognized for their diagnostic and prognostic value in cancer.
- ncRNAs mediate cell-to-cell communication, influencing cancer progression and therapy resistance.
- Xeno-microRNAs (miRNAs) from non-human genomes can also serve as biomarkers.
Conclusions:
- Circulating ncRNAs are valuable tools for non-invasive cancer detection, prognosis, and monitoring.
- Understanding ncRNA-mediated communication is key to developing novel cancer therapies.
- A comprehensive understanding of circulating ncRNAs can improve cancer management strategies.
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