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[Brain microbleeds - definition, pathophysiology and the consequences]

Marek Mazurek1, Ewa Papuć1, Konrad Rejdak1

  • 1Katedra I Klinika Neurologii Uniwersytetu Medycznego W Lublinie, Lublin, Polska.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|May 23, 2018
PubMed

Insights

Brain microbleeds, identified via MRI, are linked to aging and various neurological disorders. These small bleeds can impact brain structure and neuronal function, highlighting their clinical significance.

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Brain microbleeds are MRI-detected lesions indicating extravasated blood from damaged vessels.
  • Their presence is associated with aging, hypertension, and neurodegenerative diseases like Alzheimer's.

Purpose of the Study:

  • To review current knowledge on cerebral microbleeds.
  • To discuss their pathogenesis, detection, and impact on brain tissue.

Main Methods:

  • Utilizes Gradient Echo (GRE) and Susceptibility-Weighted Imaging (SWI) MRI sequences for visualization.
  • Reviews existing literature on microbleed pathogenesis and clinical relevance.

Main Results:

  • Microbleeds result from complex pathogenesis, with hypertensive and amyloid angiopathies being key factors.
  • Prevalence increases with age and is observed in both healthy individuals and those with neurological conditions.
  • Microbleeds may disrupt brain structure and neuronal electrical function.

Conclusions:

  • Cerebral microbleeds are significant indicators of vascular and neurological health.
  • Understanding their role is crucial for diagnosing and managing various brain disorders.
Keywords:
Alzheimer’s diseaseamyloid angiopathyhypertensive angiopathycerebral microbleedsdementia

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