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[Brain microbleeds - definition, pathophysiology and the consequences].

Marek Mazurek1, Ewa Papuć1, Konrad Rejdak1

  • 1Katedra I Klinika Neurologii Uniwersytetu Medycznego W Lublinie, Lublin, Polska.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|May 23, 2018
PubMed
Summary
This summary is machine-generated.

Brain microbleeds, identified via MRI, are linked to aging and various neurological disorders. These small bleeds can impact brain structure and neuronal function, highlighting their clinical significance.

Keywords:
Alzheimer’s diseaseamyloid angiopathyhypertensive angiopathycerebral microbleedsdementia

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Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Brain microbleeds are MRI-detected lesions indicating extravasated blood from damaged vessels.
  • Their presence is associated with aging, hypertension, and neurodegenerative diseases like Alzheimer's.

Purpose of the Study:

  • To review current knowledge on cerebral microbleeds.
  • To discuss their pathogenesis, detection, and impact on brain tissue.

Main Methods:

  • Utilizes Gradient Echo (GRE) and Susceptibility-Weighted Imaging (SWI) MRI sequences for visualization.
  • Reviews existing literature on microbleed pathogenesis and clinical relevance.

Main Results:

  • Microbleeds result from complex pathogenesis, with hypertensive and amyloid angiopathies being key factors.
  • Prevalence increases with age and is observed in both healthy individuals and those with neurological conditions.
  • Microbleeds may disrupt brain structure and neuronal electrical function.

Conclusions:

  • Cerebral microbleeds are significant indicators of vascular and neurological health.
  • Understanding their role is crucial for diagnosing and managing various brain disorders.