Related Experiment Video

Updated: Feb 10, 2026

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
05:53

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing

Published on: August 16, 2018

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Impact of Bone Fracture on Ischemic Stroke Recovery

Meng Wei1, Haiyian Lyu2, Kang Huo3

  • 1Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA. wm.3686@stu.xjtu.edu.cn.

International Journal of Molecular Sciences
|May 23, 2018
PubMed

Insights

Bone fractures can complicate stroke recovery, potentially worsening cognitive decline and impacting patient quality of life. This review explores the underlying biological mechanisms connecting bone fracture and stroke recovery.

Area of Science:

  • Neuroscience
  • Orthopedics
  • Cardiovascular Medicine

Background:

  • Stroke is a leading cause of long-term disability.
  • Hip fracture repair surgery is associated with a 4% stroke complication rate.
  • Common risk factors link bone fracture and ischemic stroke.

Purpose of the Study:

  • To review the pathophysiological mechanisms linking bone fracture and stroke recovery.
  • To highlight the understudied impact of bone fracture on stroke outcomes.

Main Methods:

  • Literature review of existing research.
  • Analysis of pathophysiological pathways.

Main Results:

  • Bone fracture can negatively influence stroke recovery.
  • Fracture timing during stroke recovery impacts cognitive decline trajectory.

Conclusions:

  • Bone fracture presents a significant challenge to stroke recovery.
  • Further research into fracture-stroke interactions is warranted to improve patient outcomes.

Keywords:
bone fracturecognitive declineinflammationstroke

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